One-year follow-up of thyroid function in 23 infants with Prader-Willi syndrome at a single center in China

Endocrine disorders are common in patients with Prader-Willi syndrome (PWS). Whether hypothyroidism is present PWS, and especially infants young children, remains unclear. The aims of this study were to evaluate thyroid function assess the prevalence dysfunction, effect growth hormone on function. Subjects 23 PWS ages 3 months years who followed for up one year. Four lost follow-up after first visit. remaining 19 treated recombinant human (rhGH). was diagnosed based a genetic analysis. Free thyroxine (FT4), free triiodothyronine (FT3), thyroid-stimulating (TSH) levels evaluated before treatment. A total 9 (9/23 = 39.1%) developed abnormal Five out (21.7%) had dysfunction during 3- 9-month period rhGH Of function, 7 (5 boys, 2 girls) central hypothyroidism, other subclinical hypothyroidism. TSH higher due maternal uniparental disomy (UPD) than 15q11-q13 deletion. high children PWS. Thyroid should be regularly monitored at both diagnosis follow-up.